Full Automation

From configuration to all calculated combinations, automatically

Enter your products, processes and equipment once. Hally-pharma automatically generates all product A → product B combinations, calculates every MACO and every ARL — regardless of the number of steps and equipment configurations.

What you configure

Your input data, infinite results

Hally-pharma handles all the combinatorial work. You configure your environment, our engine calculates everything.

Calculation strategy

MACO calculation approaches

Configure your acceptance strategies: daily therapeutic dose approach, HBEL (PDE), empirical limits (10 ppm). Hally-pharma supports multiple parallel approaches and automatically retains the most restrictive value.

Therapeutic Dose HBEL (PDE) 10 ppm Most restrictive criterion

Products

Finished product description

Enter each product: routes of administration, minimum daily dose, formulation, toxicological data, etc. Hally-pharma centralizes this data and reuses it in all cross-calculations (product A in product B and vice versa).

Route of administration Min. daily dose Formulation Toxicological data

Equipment & manufacturing processes

Manufacturing process description

This is where all the complexity lies — and where Hally-pharma delivers. You describe each process as an ordered sequence of steps. For each step, you associate one or more pieces of equipment, with the ability to define alternative configurations: 'this equipment or that equipment'.

Hally-pharma's engine then explores every possible branch of the process to identify, for each product pair, the largest shared equipment train surface area — the surface that determines the actual ARL (Acceptable Residual Limit), not a conservative approximation.

Ordered steps Multi-equipment per step Alternative configurations (OR) Surface areas per equipment

Visualization

The complexity of combinations, illustrated

In multi-step processes with alternative equipment, dozens of manufacturing paths may exist. Hally-pharma automatically analyzes them to identify the equipment trains that are truly shared and to accurately determine the total shared surface.

Product A

Product B

Product C

Weighing

Blending

Formulation

Filling

Lyophilization

Scale 1

120 cm²

Scale 2

80 cm²

Blender A

23 340 cm²

Blender B

38 280 cm²

Blender C

52 990 cm²

Tank C1

28 750 cm²

Tank C2

34 249 cm²

Filler R1

12 569 cm²

Filler R2

9 890 cm²

Lyophilizer L1

72 780 cm²

Automatic calculation of shared surfaces

Product A × Product B

Shared equipment	Product contact	Surface
Scale 1	Direct contact	120 cm²
Blender B	Direct contact	38 280 cm²

Maximum shared surface 38 400 cm²

Product A × Product C

Shared equipment	Product contact	Surface
Blender B	Direct contact	38 280 cm²
Filler R1	Direct contact	12 569 cm²
Lyophilizer L1	Indirect contact	N/A

Maximum shared surface 50 849 cm²

Product B × Product C

Shared equipment	Product contact	Surface
Blender B	Direct contact	38 280 cm²
Tank C2	Direct contact	34 249 cm²

Maximum shared surface 72 529 cm²

Generated outputs

All outputs, in one click

Once the configuration is entered, Hally-pharma calculates everything — for every product combination, in both directions.

All product A → product B combinations

The engine automatically generates all product pairs (A in B, B in A, A in C…), with no omissions and no manual errors.

MACO calculated for each approach

For each pair, all configured approaches (Therapeutic dose, PDE, 10 ppm…) are calculated and the most restrictive criterion is automatically selected.

ARL using the Hally-pharma model

Hally-pharma identifies the largest shared equipment train surface area between two products — even with alternative configurations — and calculates the ARL on this real basis, not an approximation.

Full calculation traceability

Each result is linked to its source data. You can trace everything at any time — which assumption led to which calculation.

Export and reporting

Exportable summary tables, ready to integrate into your documents.

Instant update

Add a product, modify equipment, or change an approach? All calculations are instantly recalculated across your entire facility.